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KMID : 0614620130620050288
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Korean Journal of Gastroenterology
2013 Volume.62 No. 5 p.288 ~ p.291
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Role of Fecal Calprotectin in Differentiating between Hirschsprung’s Disease and Functional Constipation
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Fatemeh Elham Mahjoub
Nasim Zahedi
Bahar Ashjai
Mohammad Taghi Haghi Ashtiani
Fatemeh Farahmand
Maryam Monajemzadeh
Leila Kashi
Heshmat Iranikhah
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Abstract
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Background/Aims: Calprotectin is a 36.5 kD calcium and zinc binding protein in the S100 protein family. Fecal calprotectinlevels are elevated in patients with inflammatory bowel disease and some other gastrointestinal disorders such as colorectalcarcinoma. We decided to evaluate the fecal calprotectin level to see if it was able to distinguish between functional andorganic causes of constipation.
Methods: Seventy-six children aged 1 to 120 months that all underwent deep rectal mucosa biopsies at Children MedicalCenter from November 2010 till September 2011 were recruited. Nineteen cases were diagnosed as Hirschsprung’s disease and 57 of the patients had nerve ganglion cells in their biopsies. Calprotectin concentration was analyzed by the ELISA method.
Results: Although there was a significant difference between the median of the two groups (p=0.036), the median was notabove the predetermined cutoff value of 50 μg/g.
Conclusions: We propose that fecal calprotectin, using the above cutoff value, has limited value in differentiating functional constipation from Hirschsprung’s disease.
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KEYWORD
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Constipation, Hirschsprung disease, Calprotectin, Feces, Pediatrics
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